Τίτλος:	Linking pre-diabetes with benign prostate hyperplasia. IGFBP-3: a conductor of benign prostate hyperplasia development orchestra?
Δημιουργός:	Protopsaltis, I Ploumidis, A Sergentanis, TN Constantoulakis, P Tzirogiannis, K Kyprianidou, C Papazafiropoulou, AK Melidonis, A Delakas, Dimitris
Χρονολογία:	2013
Γλώσσα:	Αγγλικά
Εξειδίκευση τύπου :	Άρθρο
Περιγραφή:	PLoS One. 2013 Dec 19;8(12):e81411
Περίληψη:	Benign prostatic hyperplasia (BPH) represents a pattern of non-malignant growth of prostatic fibromuscular stroma. Metabolic disturbances such us pre-diabetes and metabolic syndrome may have a role in BPH pathophysiology. A potential explanation for the above relationship involves the insulin-like growth factor (IGF) axis as well as IGF binding proteins, (IGFBPs) of which the most abundant form is IGFBP-3. Therefore, the aim of the present study was to investigate the association between intra-prostatic levels of IGF-1, IGF-2 as well as to evaluate the role of locally expressed IGFBP-3 in BPH development in pre-diabetes. A total of 49 patients admitted to the Urology department of a tertiary urban Greek hospital, for transurethral prostate resection, or prostatectomy and with pre-diabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) or both] were finally included. The majority of the sample consisted of subjects with IGT (51.0%), followed by IFG and IGT (32.7%) and isolated IFG (16.3%). For all participants a clinical examination was performed and blood samples were collected. In addition, total prostate (TP) volume or transitional zone (TZ) volume were estimated by transrectal ultrasonography. The results of the multivariate analysis regarding TP volume showed that higher PSA (p<0.001), larger waist circumference (p=0.007) and higher IGFBP-3 expression levels (p<0.001) independently predicted higher TP volume. The results regarding the volume of the TZ showed that higher PSA (p<0.001), larger waist circumference (p<0.001) and higher IGFBP-3 expression levels (p=0.024) were independently associated with higher TZ volume. Our findings show that intra-prostatic levels of IGFBP-3, PSA and waist circumference, but not overall obesity, are positively associated with prostate volume. IGFBP-3 seems to be a multifunctional protein, which can potentiate or inhibit IGF activity.
Θέμα:	Prostatic Hyperplasia Insulin-Like Growth Factor Binding Protein 3 Προστάτη Υπερτροφία Somatomedins Σωματομεδίνες
Εναλλακτικός δικτυακός τόπος:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868595/pdf/pone.0081411.pdf
Άδεια Χρήσης:	Αναφορά Παρόμοια Διανομή
Διάθεση ψηφιακού τεκμηρίου:	Πλήρης
Εμφανίζεται στις Ομάδες Τεκμηρίων:	Ουρολογία

Εξαγωγή σε:

Επιλέξτε στυλ βιβλιογραφικής αναφοράς APA - American Psychological Association Harvard