Τίτλος:	Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failure
Δημιουργός:	Giamarellos-Bourboulis, Evangelos J Poulakou, Garyfallia Nooijer, Aline de Samaras, Charilaos Ασκληπιείο Βούλας Γ.Ν., Α΄ Παθολογική Κλινική
Χρονολογία:	2022
Γλώσσα:	Αγγλικά
Εξειδίκευση τύπου :	Άρθρο
Περιγραφή:	Cell Rep Med. 2022 Feb 25;3(3):100560
Περίληψη:	Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated with an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning of progression to severe respiratory failure (SRF) or death, but access to suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating concentrations of C-reactive protein, D- dimers, interleukin-6, and ferritin among patients not receiving non-invasive or invasive mechanical ventilation during the SAVE-MORE study, offers predictive accuracy for progression to SRF or death within 14 days comparable to that of a suPAR concentration of ≥6 ng/mL (area under receiver operator characteristic curve 0.81 for both). The SCOPE score is validated in two similar independent cohorts. A SCOPE score of 6 or more is an alternative to suPAR for predicting progression to SRF or death within 14 days of hospital admission for pneumonia, and it can be used to guide treatment decisions.
Θέμα:	Covid-19 C-Reactive Protein Πρωτεΐνη C- Αντιδρώσα Biomarkers Disease Progression Ferritins Φεριτίνη Interleukin-6 Ιντερλευκίνη-6 Urokinase-Type Plasminogen Activator Ουροκινάση SARS-CoV-2
Εναλλακτικός δικτυακός τόπος:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872836/
Άδεια Χρήσης:	Αναφορά
Διάθεση ψηφιακού τεκμηρίου:	Πλήρης
Εμφανίζεται στις Ομάδες Τεκμηρίων:	Ιατρική

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