Τίτλος:	Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial
Δημιουργός:	Kyriazopoulou, Evdoxia Poulakou, Garyfallia Milionis, H. Metallidis, S. Bliziotis, Ioannis Ασκληπιείο Βούλας Γ.Ν., Α΄ Παθολογική Κλινική
Χρονολογία:	2021
Γλώσσα:	Αγγλικά
Εξειδίκευση τύπου :	Άρθρο
Περιγραφή:	Nat Med. 2021 Oct;27(10):1752-1760. Clinical Trial
Περίληψη:	Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety of anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at risk of progressing to respiratory failure as identified by plasma suPAR ≥6 ng ml-1, 85.9% (n = 510) of whom were receiving dexamethasone. At day 28, the adjusted proportional odds of having a worse clinical status (assessed by the 11-point World Health Organization Clinical Progression Scale (WHO-CPS)) with anakinra, as compared to placebo, was 0.36 (95% confidence interval 0.26-0.50). The median WHO-CPS decrease on day 28 from baseline in the placebo and anakinra groups was 3 and 4 points, respectively (odds ratio (OR) = 0.40, P < 0.0001); the respective median decrease of Sequential Organ Failure Assessment (SOFA) score on day 7 from baseline was 0 and 1 points (OR = 0.63, P = 0.004). Twenty-eight-day mortality decreased (hazard ratio = 0.45, P = 0.045), and hospital stay was shorter.
Θέμα:	Covid-19 Interleukin 1 Receptor Antagonist Protein Urokinase-Type Plasminogen Activator Ουροκινάση
Εναλλακτικός δικτυακός τόπος:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516650/
Άδεια Χρήσης:	Αναφορά
Διάθεση ψηφιακού τεκμηρίου:	Πλήρης
Εμφανίζεται στις Ομάδες Τεκμηρίων:	Ιατρική

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